Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability
نویسندگان
چکیده
Abstract Synonymous mutations in a protein coding gene lead to remarkably similar average “collateral” mutation effect size across alternative reading frames (1). Here we quantify the rarity of this feature among possible block structure codes as 0.77%. Then develop simple model evolutionary search with two types mutation. Across different step sizes and ratios types, fitness-maximizing region corresponds using single value. The analogous constant collateral observed for standard genetic code may likewise facilitate frame sequences.
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ژورنال
عنوان ژورنال: BioCosmos
سال: 2023
ISSN: ['2719-8634']
DOI: https://doi.org/10.2478/biocosmos-2023-0001